KUMJ | VOL. 23 | NO. 2 | ISSUE 90 | APRIL - JUNE, 2025
Association of Breast Cancer and Dyslipidemia in Nepali Women
Karki OB, Timilsina B, Ghimire P, Pokharel D
Abstract: Background
Breast cancer, which is a multi-factorial disease is one of the primary causes of
cancer-related mortality in women. The association of serum lipids with breast
cancer is being debated.
Objective
To examine any possible association between fasting lipid profile and breast cancer
in Nepali women.
Method
A case-control study was conducted among 36 breast cancer patients, 40 patients
with benign breast lump and 38 apparently healthy control women from February
2022 to December 2024. Ethical clearance was obtained from institutional review
committee (MEMG/IRC/500/GA) prior to study. A convenient sampling technique
was used. Data entry and analysis were done using SPSS version 20. Chi-square tests
and analysis of variance (ANOVA) were used for statistical comparisons of categorical
and continuous data respectively. P-value of <0.05 was considered statistically
significant.
Result
Of the 114 participants included in this study, 36 were malignant breast cancer
patients, 40 were benign breast lump patients and 38 controls with the mean ages
of 52.75 ± 10.39, 48.45 ± 12.78 and 45.80 ± 10.14 years respectively. The prevalence
of dyslipidemia was 75%, 25% and 26.31%, among malignant breast cancer patients,
benign breast lump patients and control group respectively with the mean value of
triglyceride (160.01 ± 78.34, 111.75 ± 60.40 and 97.99 ± 31.34) respectively and the
difference was statistically significantly (p < 0.001). In addition, the mean serum
concentrations of total cholesterol were significantly different between the three
groups (1588.36 ± 39.95, 132.09 ± 39.95 and 138.31 ± 45.34, p=0.020).
Conclusion
The overall prevalence of dyslipidemia was high in breast cancer patients in
comparison to patients with benign breast lump or normal controls.
Keyword : Breast neoplasms, Dyslipidemias, Lipids