KUMJ | VOL. 23 | NO. 2 | ISSUE 90 | APRIL - JUNE, 2025

Serum Uric Acid and its Correlation with Inflammation in Hypertension, a Hospital Based Case-control Study
Baskota D, Bhattarai N

Abstract:
Background Our lifestyle has a significant impact on levels of serum uric acid. We have attempted to correlate the patients’ uric acid levels with predictors of inflammation, such as C-reactive protein, obesity and dyslipidemia among hypertensive cases. Objective To investigate the association of uric acid with systolic and diastolic blood pressure, body mass index and waist circumference in essential hypertension. To correlate uric acid with C-reactive protein, fasting blood sugar, serum creatinine, triglycerides, high density lipoprotein and total cholesterol. Method This hospital-based case-control study included 280 participants. 150 were hypertensive cases and 130 were normotensive controls. Anthropometric measurements including waist circumference and blood pressure were taken. Body mass index was calculated from height and weight. Blood was collected for total cholesterol, triglyceride, C-reactive protein, high density lipoprotein, uric acid, creatinine and fasting blood sugar. Data were analyzed using SPSS 24, distribution expressed in frequency and percentage and correlations examined through Spearman’s rho correlation, interquartile range and median. Categorical variables each were compared between groups using χ2 test. Result There were 150 hypertension cases and 130 normotensive controls. The predictors of inflammation like waist circumference, systolic and diastolic blood pressure, body mass index, uric acid and triglyceride were significantly high among hypertensives; (p=0.000). High density lipoprotein was low among hypertensives (p=0.000). Uric acid showed significant positive correlation with waist circumference in females (p=0.000), but not in males. Body mass index, systolic and diastolic blood pressure, C-reactive protein, triglyceride and low levels of high density lipoprotein showed significant positive correlation; (p=0.000). A significant positive correlation of uric acid was seen with creatinine, (p=0.005). Fasting blood sugar and Total cholesterol failed to show any association with uric acid. Conclusion This study demonstrated that there is a strong correlation between serum UA and the metabolic predictors of inflammation, such as hypertension, C-reactive protein, triglyceride, low high density lipoprotein, high body mass index, high waist circumference, and serum creatinine, as shown by other studies that imply the interplay between metabolic disorders and inflammation
Keyword : C-reactive protein, Dyslipidemia, Hypertension, Inflammation, Uric acid