KUMJ | VOL. 15 | NO. 4 | ISSUE 60 | OCT.-DEC. 2017
Adverse Drug Reaction (ADR) Monitoring at the Eastern Regional Pharmacovigilance Centre, Nepal
Rauniar GP, Panday DR
Abstract: Background
Adverse Drug Reaction is any unintended drug consequence. It is often preventable.
In developed countries, it is among the top ten leading causes of morbidity and
mortality. However, it’s monitoring is largely unexplored in developing countries like
Nepal.
Objective
To identify and characterize the pattern of Adverse Drug Reactions at BP Koirala
Instittue of Health Science (BPKIHS), the Eastern Regional Pharmacovigilance Centre
of Nepal.
Method
It was an observational study among the patients presented to different Clinical
Departments of BPKIHS. Study duration was between July 2012 to July 2015. Adverse
Drug Reactions were documented in a structured questionnaire and analysis done,
in the department of Clinical Pharmacology and Therapeutics, using Microsoft 2013
Excel.
Result
There were total 150 Adverse Drug Reactions documented mostly in the age range
of 19-40 years (61.4%) with female preponderance (56.7%). Maximum Adverse
Drug Reactions were collected from Psychiatry (60.7%) followed by Dental surgery
(17.3%) and Internal Medicine (10.7%). Most frequent Adverse Drug Reactions were
seen with drugs primarily affecting CNS (64.7%), followed by steroids (18.0%) and
Antimicrobial drugs (12.0%). Among CNS drugs, Antidepressants (93.6%) accounted
for most documentation. Weight gain (20.1%), Fatigue (12.4%), Rash (8.1%), Acid
peptic disorder (7.7%), Headache (7.2%) and Puffiness of face (7.2%) were the most
frequently encountered Adverse Drug Reactions.
Conclusion
Most reported Adverse Drug Reactions were from young (18-40) female presented to
the department of Psychiatry. Weight gain was the most common side effect.
Keyword : Adverse Drug Reaction, BP Koirala Instittue of Health Science, Pharmacovigilance
